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Xerostomia Therapeutics Market Size, Share, Growth Analysis 2032

Xerostomia Therapeutics Size and Forecast (2025 - 2032), By Drug Class (Parasympathomimetic Drugs, Saliva Stimulants, Saliva Substitutes, Others), By distribution channel (hospital pharmacies, retail pharmacies, online pharmacies), By Route of Administration (Oral, Topical, Others), and Geography.

Report Code: PHA00738
Report Format: PDF + PPT + Excel
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Report Description

Market Overview:

The global xerostomia therapeutics market is expected to reach a high CAGR of 3.6% over the Forecast Period 2025-2032, reaching USD XX million in 2024 and USD YY million in 2032. North America leads the market because of its high prevalence of xerostomia, expanding elderly population, and well-established healthcare infrastructure. The rising prevalence of chronic diseases such as diabetes and Sjogren's syndrome, as well as increased awareness of oral health and launch, are propelling market growth. However, the negative effects of xerostomia drugs, as well as their availability, are fuelling market growth in some cases.

 

Market Dynamics:

Growing Prevalence of Xerostomia Driving Demand for Effective Therapeutics

The increasing prevalence of xerostomia, particularly among the elderly, is a significant driver of the xerostomia therapies sector. According to a 2020 study published in the Journal of the American Dental Association, the global prevalence of xerostomia ranges from 0.9% to 64.8%, with higher rates recorded in the elderly and individuals with specific medical conditions. As the patient population grows, so will the demand for effective xerostomia treatments.

 

Launch of Novel Xerostomia Drugs Boosting Market Growth

The development of new xerostomia drugs with higher efficacy and safety profiles is expected to greatly drive market growth. For example, in 2021, the FDA approved Oyster Point Pharma's Tyrvaya (varenicline solution) nasal spray to treat Sjogren's syndrome-related dry mouth. The development of such innovative treatments is expected to broaden treatment options for xerostomia patients while driving market growth.

 

Side Effects Associated with Xerostomia Drugs Restraining Market Growth

Certain xerostomia treatments may have side effects that limit their use and economic potential. Side effects of parasympathomimetic medicines, such as pilocarpine and cevimeline, include perspiration, nausea, and diarrhoea. The availability of alternative treatments such as acupuncture and herbal remedies may further restrict the expansion of the xerostomia therapeutics sector.

 

Segment Overview:

Parasympathomimetic Drug Segment to Dominate the Market

Based on their well-established efficiency in increasing salivary flow, parasympathomimetic medications are expected to account for the bulk of the market over the forecast period. Pilocarpine and cevimeline are the two most commonly prescribed parasympathomimetic medicines for xerostomia. The FDA approved a new formulation of pilocarpine hydrochloride oral spray (Salagen) for the treatment of xerostomia in 2020, which is projected to accelerate the segment's growth.

The saliva substitutes industry is also expected to grow significantly in the coming years as over-the-counter saliva substitute products become more widely available and convenient to use. Colgate-Palmolive, a worldwide oral care company, launched Colgate Hydris, a new saliva substitute product, in 2021, with the purpose of giving long-term relief from dry mouth.

The hospital pharmacy distribution channel segment had the highest revenue share in 2020, owing to the increasing number of xerostomia patients seeking diagnosis and treatment in hospitals. However, the online pharmacies category is predicted to grow at the fastest CAGR throughout the projection period, owing to the increased demand for online prescription purchases and the convenience offered by e-commerce platforms.

 

Regional Outlook:

North America to Dominate the Global Xerostomia Therapeutics Market

North America is expected to dominate the global xerostomia treatments market over the forecast period, owing to factors such as xerostomia's high prevalence, a rising geriatric population, favourable reimbursement policies, and the strong presence of significant industry participants. In 2020, the United States accounted for the largest part of the North American market.

The Asia Pacific region is predicted to grow at the quickest CAGR between 2024 and 2031, owing to factors such as a large patient population, improved healthcare infrastructure, increasing healthcare expenditure, and growing awareness of oral health. Sun Pharma, an Indian pharmaceutical business, will introduce Cequa (cyclosporine ophthalmic solution), a novel xerostomia drug, to the Indian market in 2021, expanding therapy options for xerostomia patients.

 

Competitive Intelligence:

The worldwide xerostomia therapeutics market is rather competitive, with numerous significant players operating in it. Leading companies are increasing their market position through activities like new product development, geographic expansion, and alliances. For example, in 2020, Syndax Pharmaceuticals, a biopharmaceutical company based in the United States, signed a licensing agreement with Incyte Corporation to develop and commercialise axatilimab, a novel therapy for the treatment of chronic graft-versus-host disease (cGVHD), which frequently causes xerostomia. GlaxoSmithKline plc, Pfizer Inc., Sun Pharmaceutical Industries Ltd., Lupin Limited, Parnell Pharmaceuticals Holdings Ltd., and OraPharma, Inc. are some of the leading market players.

 

Analyst Opinion:

The xerostomia therapeutics market is expected to grow gradually in the coming years, driven by factors such as rising xerostomia prevalence, the launch of novel treatments, and increased awareness of oral health. To ensure long-term growth, market participants must address issues such as the side effects of xerostomia drugs and the availability of alternative treatments. Strategies such as collaborative research, the creation of targeted medications, and patient information campaigns will be crucial in capitalising on growth opportunities, particularly in emerging markets.

 

Major Players:

  • GlaxoSmithKline plc

  • Pfizer Inc.

  • Sun Pharmaceutical Industries Ltd.

  • Lupin Limited

  • Parnell Pharmaceuticals Holdings Ltd.

  • OraPharma, Inc.

  • Pharmascience Inc.

  • Hikma Pharmaceuticals PLC

  • Fresenius Kabi AG

  • Teva Pharmaceutical Industries Ltd.

 

Key Developments:

  • In March 2022, GlaxoSmithKline plc reported encouraging findings from a Phase III clinical trial of its investigational medication, fezolinetant, for the treatment of moderate to severe vasomotor symptoms associated with menopause, which frequently result in xerostomia.

  • Sun Pharmaceutical Industries Ltd. gained FDA clearance for its New Drug Application (NDA) for Cequa (cyclosporine ophthalmic solution), recommended for the treatment of dry eye illness and xerostomia associated with Sjogren's syndrome, in January 2022.

Table of Content

1. INTRODUCTION

   1.1. Market Definitions & Study Assumptions

   1.2. Market Research Scope and Segment 

   1.3. Research Methodology

2. EXECUTIVE SUMMARY

   2.1. Market Overview & Insights

   2.2. Segment Outlook

   2.3. Region Outlook

3. COMPETITIVE INTELLIGENCE 

   3.1. Companies Financial Position

   3.2. Company Benchmarking—Key Players

   3.3. Market Share Analysis -- Key Companies

   3.4. Recent Companies Key Activities

   3.5. Pricing Analysis

   3.6. SWOT Analysis

4. COMPANY PROFILES (Key Companies List by Country) (Premium)*

5. COMPANY PROFILES

   5.1. GlaxoSmithKline plc

   5.2. Pfizer Inc.

   5.3. Sun Pharmaceutical Industries Ltd. 

   5.4. Lupin Limited

   5.5. Parnell Pharmaceuticals Holdings Ltd.

   5.6. OraPharma, Inc.

   5.7. Pharmascience Inc.

   5.8. Hikma Pharmaceuticals PLC

   5.9. Fresenius Kabi AG

   5.10. Teva Pharmaceutical Industries Ltd.*

6. MARKET DYNAMICS

   6.1. Market Trends

       6.1.1. Growing Prevalence of Xerostomia Driving Demand for Effective Therapeutics

       6.1.2. Increasing Focus on Development of Targeted Therapies

       6.1.3. Rising Adoption of Artificial Intelligence and Machine Learning in Drug Discovery

   6.2. Market Drivers 

       6.2.1. Launch of Novel Xerostomia Drugs Boosting Market Growth

       6.2.2. Increasing Awareness About Oral Health and Xerostomia

       6.2.3. Growing geriatric population susceptible to Xerostomia

   6.3. Market Restraints

       6.3.1. Side Effects Associated with Xerostomia Drugs Restraining Market Growth

       6.3.2. Availability of Alternative Treatments for Xerostomia

   6.4. Market Opportunities

   6.5. Porter's Five Forces Analysis

       6.5.1. Threat of New Entrants

       6.5.2. Bargaining Power of Buyers/Consumers

       6.5.3. Bargaining Power of Suppliers

       6.5.4. Threat of Substitute Products

       6.5.5. Intensity of Competitive Rivalry

   6.6. Supply Chain Analysis  

   6.7. Value Chain Analysis

   6.8. Trade Analysis

   6.9. Pricing Analysis

   6.10. Regulatory Analysis 

   6.11. Patent Analysis

   6.12. SWOT Analysis

   6.13. PESTLE Analysis

7. BY DRUG CLASS (MARKET SIZE/VALUE (US$ Mn), SHARE (%), MARKET FORECAST (%), YOY GROWTH (%)-- 2025-2032)  

   7.1. Parasympathomimetic Drugs

       7.1.1. Pilocarpine

       7.1.2. Cevimeline

   7.2. Saliva Stimulants

       7.2.1. Anetholetrithione

       7.2.2. Interferon-alpha

   7.3. Saliva substitutes  

       7.3.1. Oral Sprays

       7.3.2. Oral Gels

       7.3.3. Oral Rinses

   7.4. Others

       7.4.1. Dexmedetomidine

       7.4.2. Amifostine

8. BY DISTRIBUTION CHANNEL (MARKET SIZE/VALUE (US$ Mn), SHARE (%), MARKET FORECAST (%), YOY GROWTH)--2025-2032)

   8.1. Hospital Pharmacies

       8.1.1. Inpatient Pharmacies

       8.1.2. Outpatient Pharmacies

   8.2. Retail Pharmacies

       8.2.1. Chain Pharmacies

       8.2.2. Independent Pharmacies  

   8.3. Online pharmacies

       8.3.1. Company-owned Online Pharmacies

       8.3.2. Third-party Online Pharmacies

9. BY ROUTE OF ADMINISTRATION (MARKET SIZE/VALUE (US$ Mn), SHARE (%), MARKET FORECAST (%), YOY GROWTH (%)-- 2025-2032)

   9.1. Oral

       9.1.1. Tablets

       9.1.2. Capsules

       9.1.3. Oral Solutions

   9.2. Topical

       9.2.1. Oral Sprays

       9.2.2. Oral Gels

   9.3. Others

       9.3.1. Parenteral

       9.3.2. Transdermal patches

10. BY REGION (MARKET SIZE/VALUE (US$ Mn), SHARE (%), MARKET FORECAST (%), YOY GROWTH (%)-- 2025-2032)*

    10.1. North America

        10.1.1. United States  

        10.1.2. Canada

        10.1.3. Mexico

    10.2. South America

        10.2.1. Brazil

        10.2.2. Argentina

        10.2.3. Rest of South America

    10.3. Europe

        10.3.1. Germany

        10.3.2. United Kingdom

        10.3.3. France

        10.3.4. Italy  

        10.3.5. Spain

        10.3.6. Russia

        10.3.7. Rest of Europe

    10.4. Asia-Pacific

        10.4.1. China

        10.4.2. Japan

        10.4.3. India 

        10.4.4. Australia

        10.4.5. South Korea

        10.4.6. Rest of Asia-Pacific

    10.5. Middle-East

        10.5.1. UAE  

        10.5.2. Saudi Arabia

        10.5.3. Turkey

        10.5.4. Rest of Middle East

    10.6. Africa

        10.6.1. South Africa

        10.6.2. Egypt  

        10.6.3. Rest of Africa

 

*NOTE: All the regions mentioned in the scope will be provided with (MARKET SIZE/VALUE (US$ Mn), SHARE (%), MARKET FORECAST (%), YOY GROWTH (2025-2032)

Scope of the Report

By Drug Class:

  • Parasympathomimetic Drugs

  • Saliva stimulants

  • Saliva substitutes

  • Others

By Distribution Channel:

  • Hospital Pharmacies

  • Retail pharmacies

  • Online pharmacies

By Route of Administration:

  • Oral

  • Topical

  • Others

By Region:

  • North America

  • Europe

  • Asia-Pacific

  • Latin America

  • Middle East & Africa

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